Open AccessClomiphene Citrate Combined with Tamoxifen Citrate versus Letrozole for Inducing Ovulation in Patients with Clomiphene Citrate -Resistant Polycystic Ovary Syndrome
Publication year - 2019
Publication title -
journal of gynecology and reproductive medicine
Language(s) - English
Resource type - Journals
ISSN - 2576-2842
DOI - 10.33140/jgrm.03.02.04
Subject(s) - letrozole , polycystic ovary , clomifene , medicine , ovulation induction , ovulation , pregnancy rate , miscarriage , gynecology , tamoxifen , pregnancy , infertility , biology , hormone , insulin , cancer , insulin resistance , breast cancer , genetics
This prospective observational study was conducted on 242 patients with clomiphene citrate (CC) resistantpolycystic ovary syndrome (PCOS) who were allocated into two regimens of induction of ovulation, the firstgroup(n=128) received both CC and tamoxifen and the second (n=114) received letrozole. The ovulationrate, endometrial thickness, number of dominant follicles, pregnancy rate, miscarriage rate and live birthrate were found comparable between the two groups. Combined therapy with CC and tamoxifen is beneficialin patients with PCOS who failed to respond to CC alone.