Open AccessThe Immune Cells and Its Link to COVID-19
Publication year - 2020
Publication title -
journal of clinical review and case reports
Language(s) - English
Resource type - Journals
ISSN - 2573-9565
DOI - 10.33140/jcrc.05.07.03
Subject(s) - cytokine storm , cytokine , immune system , immunology , pneumonia , disease , pandemic , viral pneumonia , inflammation , covid-19 , medicine , biology , infectious disease (medical specialty)
World health organization has declared SARS-CoV-2 infection as a worldwide pandemic on March 11, 2020 and it is continuouslyaffecting public health throughout the globe. The disease progresses from mild symptoms to a pneumonia like condition withsevere inflammation of the respiratory tract due to cytokine release or cytokine storm that is the major characteristic of thisdisease. T cells numbers decrease and become exhausted in COVID positive patients this might be due to excessive amountof IL 10, IL 6, and TNFα. CD8+T cells and NK cells have showed functional impairment on differentiation, maturation andadequate amount cytokine production which lead to compromise the host immune response against SARS-CoV-2 infection.IFNƳ behaves as a protective cytokine at early or recovery stages and at severe stage, it acts as more pathogenic by inducinganti-viral responses. This review has summarized the current states of immune responses regarding SARS-CoV-2 infection. Itmight be helpful on offering new understandings and therapeutic approaches for COVID-19.