Open AccessNeuroprotection in Perimenopause New Insights for Hormone Therapy
Publication year - 2020
Publication title -
journal of clinical review and case reports
Language(s) - English
Resource type - Journals
ISSN - 2573-9565
DOI - 10.33140/jcrc.05.04.03
Subject(s) - neuroprotection , menopause , brain aging , window of opportunity , neuroscience , dementia , dopamine , medicine , estrogen , endocrine system , psychology , hormone therapy , hormone , endocrinology , cognition , disease , real time computing , computer science , cancer , breast cancer
Endocrine and Neural Senescence overlap by intertwined complexfeedback loops. The variable levels of estradiol, progesterone,DHEA(S), and neurotransmitters -GABA, serotonin, dopamineand glutamate dependent on sexual steroids make women’s brainto suffer from the menarche to menopause, perimenopause beinga “critical period”, “a neurological transition state” offering to thescientific and medical communities a “window of opportunity” todelay the onset of brain aging, The modern medical communitiesare moving from focusing on the treatment of already identifieddementia to develop strategies for accurate depiction of predementiaconditions/risk factors for brain aging, for prevention and slowinga demented status to progress from early stages of endocrine agingprocess [1].