Neuroprotection in Perimenopause New Insights for Hormone Therapy

Endocrine and Neural Senescence overlap by intertwined complexfeedback loops. The variable levels of estradiol, progesterone,DHEA(S), and neurotransmitters -GABA, serotonin, dopamineand glutamate dependent on sexual steroids make women’s brainto suffer from the menarche to menopause, perimenopause beinga “critical period”, “a neurological transition state” offering to thescientific and medical communities a “window of opportunity” todelay the onset of brain aging, The modern medical communitiesare moving from focusing on the treatment of already identifieddementia to develop strategies for accurate depiction of predementiaconditions/risk factors for brain aging, for prevention and slowinga demented status to progress from early stages of endocrine agingprocess [1].