Open AccessLangerhans cell histiocytosis (LCH) presenting as pneumothorax and neck lymphadenopathy
Publication year - 2020
Publication title -
journal of clinical review and case reports
Language(s) - English
Resource type - Journals
ISSN - 2573-9565
DOI - 10.33140/jcrc.05.01.13
Subject(s) - medicine , pathology , cervical lymphadenopathy , histopathology , lymph node , langerhans cell histiocytosis , histiocytosis , lung , biopsy , lymph node biopsy , cervical lymph nodes , disease , cancer , metastasis
Langerhans Cell Histiocytosis (LCH) is a rare clonal disease characterized by dendritic cells infiltration in various mainorgans. We report a 6-month-old infant with severe respiratory distress, cervical lymphadenopathy, and reddish skin rasheson face. Diagnostic work up revealed spontaneous pneumothorax on Chest X-ray (CXR). Multiple thin-walled lung cysts andemphysema was discovered on spiral chest CT scan. Lung tissue and cervical lymph node biopsy revealed dendritic cellsinfiltration. Broncho alveolar lavage (BAL), cervical lymph node and lung tissue biopsy was performed and histopathologywas assessed. It was suggestive of LCH with positive immunohistochemistry markers including CD1a, CD68 and S100.