Data Analyses with ImageJ Software in Diabetic Retinopathy, By Processing the Optical Coherence Tomography Images

The study is based on Optical Coherence Tomography images resulting from investigation of 24 patients (with a total of 33eyes) with non-proliferative diabetic retinopathy and of 19 patients (with a total of 26 eyes) without diabetes mellitus ascontrol group. Patients’ age was between 43 and 92 years old, with a mean age of 66.4 years for first group, and a mean ageof 67.6 years for the second one. From this large group, after the first data evaluation, we selected patients aged 40 to 65.We evaluated daily each patient, at 9 am, 12 pm, 3 pm and 6 pm, through glycemic level and Optical Coherence Tomographyinvestigation using Macular Cube 512x128 images acquisition type. In the same time, we made specifically measurementsof photoreceptor and retinal pigment epithelium layers thickness using ImageJ software. We analysed comparatively datagiven by Optical Coherence Tomography tool and those obtained through direct thickness measurements for three macularzones: one central (foveola) and two circulars (para-foveolar and peri-foveolar), having 1 mm, 3 mm, respectively 6 mmin diameter. We concluded that age and time of the day are significantly factors that influence the diabetic retinopathy. Wealso suggest this method as further investigation tool mostly for patients at the beginning of illness discovering, in order todiminishing and even stopping its evolution.