Regio-Selective Reaction, Spectroscopic Characterization and Computational Chemical Study of (Hesperidin) Hesperetin-7-O-Rutinoside Analogs as Antimicrobial Agents

Flavonoids display a strong antioxidant and radical scavenging activity and seem to beassociated with reduced danger for certain chronic diseases, the prevention of some cardiovascular sicknesses and certain types of cancerous processes [1-4]. Flavonoids show also antiviral, antimicrobial, and anti-inflammatory activities, helpful on capillary fragility and prevent human platelet aggregation, antiulcer and antiallergenic [5-11]. Though, the actual in vivo mechanism of action is largely unknown. Most studies have attentivein vitro tests at amounts much higher than in humans,however few clinical investigations have been carried out around the diseases [12].Additional clinical trials are required to evaluate a more precise correlation between flavonoids consumption and human health benefits [13]. The possible mechanism of potential experimentalactionhas been studied [14]. Citrus juices attitude among the most significant phenolicrich dietary sources [15].