HDFx, a Natural Biologic is Associated with Elevated DNA Methylation, Reduced DNA Oxidation and Telomerases Down-regulation in Macrophages and Monocytes Derived from Surviving Animals Subjected to Experimental Shock and Burns: Males vs. Females and Relation to Resistance Against Bacterial & Viral Infections

Circulatory shock and burns are significant and sustained states ofhypoperfusion and lead to decreases in circulating blood volumecombined with decreased tissue and organ oxygenation. Thishypoperfusion state often causes sepsis resulting in a state of“multiple organ failure” [1-3]. Due to severe body burns, battlefield casualties are most susceptible to the latter resulting innumerous loss of lives.