Fatigue in Multiple Sclerosis: Current Concepts and Future Challenges

Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). During the disease process, affected patients can experience sensory, motor, cognitive and emotional symptoms. Fatigue is also a common and debilitating complain that can affect up to 75% of MS patients at some point during their life [1]. By definition, it is a reversible subjective lack of mental and/or physical energy that can alter normal functioning. The symptom severity can fluctuate in a way that it is usually higher at the end of the day, and during hot or humid environment [1].