Open AccessAetiology of Neuropathic Pain (NP) Along with Role of Gabapentinoids Like Pregabalin and Gabapentin in Treating the Excruciating Pain Besides Other Newer Alternatives-a Systematic Review
Publication year - 2020
Publication title -
journal of anesthesia and pain medicine
Language(s) - English
Resource type - Journals
ISSN - 2474-9206
DOI - 10.33140/japm.05.01.05
Subject(s) - pregabalin , gabapentin , neuropathic pain , medicine , oxcarbazepine , carbamazepine , opioid , duloxetine , peripheral neuropathy , anesthesia , epilepsy , diabetes mellitus , psychiatry , alternative medicine , receptor , pathology , endocrinology
Neuropathic pain (NP) by definition is a problem that involves the somatosensory system either as a manifestation as diseaseor as a lesion. Lot of differing causes either of central/peripheral origin can stimulate NP and that might affect life’s qualitybadly. Worldwide prevalence of NP varies from 6.9-10% with spinal cord injury (SCI) explaining 40% of them. The 2ndcommonest cause is diabetic peripheral neuropathy (DPN) that accounts for 22-28% of type 2 diabetes mellitus (T2DM).After having reviewed thoroughly how to manage diabetic neuropathic pain here we decided to conduct a systematic reviewon varying causes of NP and the role of gabapentenoids in managing the excruciating pain. Besides newer opioid analoguesnot having addictive potential like fentanyl matrix with its availability in intradermal formulations, delta opioid receptoragonist BBI-11008, an innovative analog N-(1-benzylpiperidin-4-yl)-4-fluorobenzamide (LMH2), that is like haloperidol,along with advantages of Gabapentin-ER as well as therapy of trigeminal neuralgia with anticonvulsants like carbamazepineand use in Immunotherapy utilizing 14,18 anti GD2 antibody (ch14.18) associated excruciating pain and in Meralgiaparaesthetica (MP) is discussed besides alternative therapies when gabapentenoids fail.