Open AccessEstimation of Furosemide in Pharmaceutical Preparation Samples
Publication year - 2020
Publication title -
international journal of forensic research
Language(s) - English
Resource type - Journals
ISSN - 2767-2972
DOI - 10.33140/ijfr.01.01.08
Subject(s) - molar absorptivity , furosemide , absorbance , relative standard deviation , chromatography , dosage form , chemistry , accuracy and precision , analytical chemistry (journal) , materials science , mathematics , detection limit , optics , statistics , physics , organic chemistry
A simple, accurate, precise, rapid, economical and sensitive ultraviolet spectrophotometric method has been developed for the determination of Furosemide in pharmaceutical preparations, which shows maximum absorbance at 228 nm in. Beer’s law was obeyed in the range of 1 -10 μg/ ml, with molar absorptivity of 3.5×104 L.mol-1.cm-1, relative standard deviation of the method was less than 1.4%, and accuracy (average recovery %) was 100 ± 1.0. The method was successfully applied to the determination of Furosemide in some pharmaceutical formulations (tablets, Oral solution and injection) samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of Furosemide in true samples.