Polyuria is the Cause of Diabetes Complications

Statement of the problem: The blood plasma glucose-protein interactions model (the glycation theory) for the studyof chronic diabetes complications has failed to find cure. Available data showing that polyuria reduced blood plasmaconcentrations of thiamine (a vasodilator) in diabetes mellitus patients to 25% of concentration level needed to sustainvasodilatation in the microcirculation of normal healthy persons have been used to propose a new theory.Theory: Polyuria-induced vitamin deficiency in blood plasma causes vasoconstriction in the microcirculation; impairing theexchange of nutrients, gases and particles between blood and tissue causing tissue damage in organs with microcirculationeveryday. Over time, the accumulated damage manifests as organ failure described as “diabetes complications”.Hypothesis: Supplementation with vasodilators to ensure 24-hour vasodilatation in the microcirculation will halt tissuedamage to allow natural healing.Methodology and Findings: A tablet containing niacin, thiamine and calcium-d-pentothenate was prepared and given todiabetes patients in open trial to ingest, one-a-day just before bed, over seven years. Cures reported included early-stagesymptoms of chronic complications such as; ulcers, nephropathy, retinopathy and peripheral neuropathy. Continued useafter the initial cure has prevented developments of new symptoms.Conclusion and Significance: The multiple cures of chronic complications affecting all organs by the vitamin supplementationdemonstrate the validity of the polyuria theory. This is a breakthrough in diabetes research. That the tablet contains, wellcharacterised substances with no known side effects, is additional bonus. Patients will not require hospital treatment or needsupervision by trained medical personnel; thus reducing treatment costs. The therapy itself is not expensive to buy.Peoplewith diabetes will not anymore live with the threat of blindness, amputation, kidney failure, stroke and heart problems.