Open AccessLevels Orexigenic and Anorexigenic Hormones in Adolescents with Obesity
Publication year - 2019
Publication title -
international journal of diabetes and metabolic disorders
Language(s) - English
Resource type - Journals
ISSN - 2475-5451
DOI - 10.33140/ijdmd.04.04.05
Subject(s) - medicine , obesity , ghrelin , orexigenic , insulin resistance , growth hormone receptor , endocrinology , population , hormone , abdominal obesity , gastroenterology , growth hormone , receptor , metabolic syndrome , environmental health , neuropeptide y receptor , neuropeptide
Background: About 20 thousands of new cases of obesity (Ob) are first registered in children and adolescents in Ukraineannually (morbidity 2.72/1000, prevalence 13.50/1000 of the corresponding population on 01.01.2016). AdolescentOb shows catastrophic rise (prevalence 8.9/ 1000 in 2001 vs 28.3/1000 in 2015). Completely unclear the role of Ghrin the etiopathogenesis of obesity in adolescents with HD.Material and Methods: A total of 39 obese children with HD (14 boys, 15, 1 ± 1, 4 y) and 14 healthy control (mean age14, 6 ± 1, 2 y) were included into the study. Among patients with HD- 16 patients (41, 03 %) had visceral abdominalobesity (VAOb), 23 patients (58, 97 %) had gluteofemoral obesity (GFOb). Serum Ghrelin, Insulin level, HOMA-IRwere studied. Such studies are conducted in Ukraine for the first time.Results: Overweightt was revealed in 15 (38, 5 %) patients with HD, ObI – in 8 (20, 5 %) people, ObII – in 10 (25, 6%) persons, ObIII – in 6 people (15, 4 %). The signs of insulin resistance (HOMA-IR > 2, 77; IRI > 20 μIU/mL) werenoted in 60 % patients. Serum Ghr level was found significantly lower in obese adolescents compared to that of controlgroup and was dependent on the degree of Ob. The level of Ghr was the lowest (582, 58 ± 59, 37 ng/mL) in patientswith ObIII. The level of Ghr was significantly lower (p <0.05) in patients with VAOb than with GFOb (656, 63 ± 113,16 vs 1212, 13 ± 114, 6 ng/ml, respectively). The levels of hyperinsulinemia and insulin resistance were increased withan increase in the degree of obesity.Conclusion: Hypothalamic dysfunction, associated with obesity in adolescents, is accompanied by a low serum Ghrlevel. A high degree of obesity is accompanied by a greater decrease in the Ghr level. A significantly lower Ghr levelwas registered in abdominal Ob comparing to gluteofemoral type of obesity. Further studies the relationship of Ghrlevel, insulin resistance and hyperinsulinemia in obese adolescents with hypothalamic dysfunction are required.