E-Cadherin Expression as risk factor Lymph Nodes Metastatic of Paediatric Thyroid Carcinoma

Background: Although Paediatric Thyroid Carcinoma (PTC) has excellent prognosis, certain cases exhibit aggressiveclinical manifestations. Treatment of PTC patient is therefore littered with controversies.Purpose: We assessed the expression of RET/PTC1, TGFβRII and E-cadherin in PTC and metastatic lymph nodes,in order to investigate the mechanism underlying the mainly indolent but potentially aggressive of PTC.Methods: A retrospective study included 93 PTC patients treated in our hospital were included in this study. Allprimary tumours and metastatic lymph nodes were immunohistochemically stained to evaluate the expression ofRET/PTC1, TGF βRII and E-cadherin. Clinical characteristics also evaluated to predict the metastasis.Results: A total of 77 (82.3%) were positive for RET/PTC1, 61(65.6%) positive for TGF βRII and 63 (67.7%)positive for E-cadherin. Even though Capsular Invasion, Size of tumours, TGF βRII and RET/PTC1 expressionwere significantly correlated with metastasis with multivariate analysis E-cadherin is the protein which was stronglycorrelated with metastasis (P<0.001 OR = 263.53; 95% CI (21.88-3172.72).Conclusion: Our results suggest that the decreased expression of E-cadherin in primary lesion is correlated withregional lymph node for metastasis in PTC. E-cadherin may be useful as a marker for metastatic potential in PTC.The expression of transforming growth factor βRII in PTC was shown to be associated with clinically aggressivecharacteristics. RET/PTC1 rearrangement still remains the cause of spontaneous PTC in Indonesia