Sensitive Skin Syndromes and Transient Receptors Potential (TRP) Channels in Sensitive Skin

Sensitive skin is a prevalent skin condition affecting both female and male worldwide without the presence of perceivable signs. The associations between sensitive skin and pre-existing skin diseases of atopy and dermatitis, dry skin, rosacea and food hypersensitivity in the gut with cognitive complications are referred to as Sensitive Skin Syndrome (SSS), making this disease more complex. Neurogenic and non-neurogenic inflammation, epidermal barrier defects, TRP ions channels interplay with the central nervous system combining with subsequent perceptive cognitive motor behaviour appears to be the main pathogenetic mechanism. Further research and studies of this intriguing condition may further enlighten us on how different systems of the body: skin, nervous system, cognition and gut integrate functionally and pathologically as a whole. Keywords: Sensitive skin syndromes, Sensitive skin, Transient