Cerebrall Autosomal Dominant Artheriopathy with Subcortical Infarcts and Leukoencephalopathy

CADASIL is a hereditary cerebrovascular disease that affects smallvessels and usually causes recurrent subcortical infarctions withwhite matter involvement. It is usually closely related to migrainehistory, in advanced cases a subcortical dementia usually occurs. Itis a disease characterized by a picture of progressive deterioration,and in very advanced stages a pseudobulbar paralysis can occur. In1955 some cases were described that were called hereditary vasculardementia, later in 1977 it was renamed hereditary multi-infarctdementia, in 1991 they came to be referred to as familial arteriopathicleukoencephalopathy [1]. Finally, with the discovery of the geneinvolved in the disease, it was renamed CADASIL in 1996 by Joutel.As we can see, the pathological discovery of the disease is of recentdiscovery, thus adopting the various nomenclatures described above.