Effects of Curcuma Longa and Galega Orientalis Herbal Remedies on Homeostatic Renal Functions in Rats with Diabetes Mellitus and Acute Renal Failure

Aim: To study the effects of phytopreparations Curcuma longa and Galega orientalis on homeostatic renal functions in ratswith diabetes mellitus (DM) and acute renal failure (ARF) models.Materials and methods: The experiments were performed in 2 series on male Wistar rats (n = 60) with a model of diabetesmellitus (the 1-st one) and acute renal failure (the 2-nd one). In both series, the animals were divided into 3 groups: rats of the1-st group were kept on standard feed, the rats of the other groups were got additionally to the feed turmeric (the 2-nd group)or galega (the 3-d group) (2% of feed weight). On the 3-d day of the experiment, the study of diuretic and ionuretic renalfunctions on an empty stomach and after water loading was performed. The concentration of ions in urine and plasma wasdetermined by flame photometry; osmotic concentration of biological fluids - by cryoscopy; blood biochemical parameters–by colorimetric method.Results: In diabetic against both at the background and following water loading polyuria compared to the control animals wasobserved. Intake of Curcuma longa resulted in a slight decrease of polyuria, but an increase in the Na+ and K+ concentrationin the urine. It has been shown that turmeric and galega have a hypoglycemic effect and contribute to the normalization ofplasma homeostatic parameters by improving the functional state of the kidneys. This effect was most pronounced followingturmeric intake. In rats with acute renal failure both phytopreparations did not cause the changes in renal functions.Conclusion: Phytopreparations of turmeric and galega in diabetes have a hypoglycemic effect, contribute to the normalizationof plasma homeostatic parameters and improve the functional state of the kidneys. In acute renal failure, these herbal remedieshave almost no effect on osmotic and ion-regulating responses.