Open AccessPressurized Liquid Extraction of Hemp Residue and Purification of the Extract with Liquid-Liquid Extraction
Author(s) -
János Béri,
Sára Ágnes Nagy,
Attila Kovács,
Erika Vági,
Edit Székely
Publication year - 2021
Publication title -
periodica polytechnica. chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.322
H-Index - 19
eISSN - 1587-3765
pISSN - 0324-5853
DOI - 10.3311/ppch.18456
Subject(s) - chromatography , residue (chemistry) , supercritical fluid extraction , hexane , methanol , extraction (chemistry) , solvent , chemistry , mass transfer , factorial experiment , supercritical fluid , partition coefficient , yield (engineering) , ternary operation , materials science , organic chemistry , mathematics , composite material , statistics , programming language , computer science
The first semi-continuous Pressurized Liquid Extraction (PLE) of hemp threshing residue with ethanol was carried out according to a 32 full factorial experimental design with pressure and temperature as independent variables at 8-10-12 MPa and 323-333-343 K, respectively. The total- and cannabidiol (CBD) yield curves were fitted to the modified two-parameter Brunner equation. Best results, concerning CBD, can be achieved at 12 MPa and 343 K. Solvent mass-consumption and operation time were considerably decreased compared to a previous supercritical fluid extraction study on the same material. Furthermore, the concentration profiles were evaluated to study the mass transfer. The winterized dry extracts were further studied in a methanol-hexane-water ternary system concerning CBD distribution ratio, showing high methanol dependency.