Open AccessProduction of Rosuvastatin Calcium Nanoparticles Using Gas Antisolvent Technique
Author(s) -
Mohammad Najafi,
Nadia Esfandiari,
Bizhan Honarvar,
Zahra Arab Aboosadi
Publication year - 2021
Publication title -
periodica polytechnica. chemical engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.322
H-Index - 19
eISSN - 1587-3765
pISSN - 0324-5853
DOI - 10.3311/ppch.16629
Subject(s) - differential scanning calorimetry , dynamic light scattering , fourier transform infrared spectroscopy , dissolution , particle size , bioavailability , scanning electron microscope , analytical chemistry (journal) , chemistry , bar (unit) , nanoparticle , materials science , particle (ecology) , chromatography , chemical engineering , nuclear chemistry , nanotechnology , thermodynamics , organic chemistry , composite material , bioinformatics , physics , oceanography , biology , meteorology , geology , engineering
The activity of pharmaceutical substances crucially depends on the bioavailability of the substances. The bioavailability of drugs in body and their rate of dissolution in the biological fluids are increased if the particle size is decreased. In the present paper, the Gas Anti-Solvent (GAS) method was used to lower the size of rosuvastatin particles. The effects of temperature (313–338 K), pressure (105–180 bar) and initial solute concentration (20–60 mg/ml) were evaluated by Response Surface Methodology (RSM). The optimum initial solute concentration, temperature and pressure were found to be 20 mg/ml, 313 K and 180 bar, respectively which resulted in the minimum particle size. Furthermore, the particles were characterized by Differential Scanning Calorimetry (DSC), Dynamic Light Scattering (DLS), Fourier Transform Infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and X-Ray Diffraction (XRD). The analyses showed that the rosuvastatin particles (60.3 nm) precipitated by GAS process become significantly smaller than the initial particles (45.8 µm).