Open AccessEffect of Spirulina (Arthrospira platensis) on blood uric acid, hemoglobin and kidney histo-texture of mice treated with acetaminophen
Author(s) -
M.` Zeenat,
Shafina Shawon Sharmin,
Md. Toriqul Islam,
Khaled Mahmud Sujan,
Md. Iqramul Haque,
Tapan Saha,
Maidul Islam
Publication year - 2019
Language(s) - English
DOI - 10.33109/bjvmjj19lam1
Subject(s) - spirulina (dietary supplement) , uric acid , hemoglobin , acetaminophen , kidney , arthrospira , food science , ingestion , medicine , biology , zoology , biochemistry , cyanobacteria , raw material , ecology , genetics , bacteria
Background: Acetaminophen is a medication used to treat pain and fever. It is typically used for mild to moderate pain relief. Spirulina is a biomass of cyanobacteria that cultivated worldwide and used as a dietary supplement or whole food. It is also used as a feed supplement in the aquaculture, aquarium, and poultry industries. The present study was undertaken to determine the effect of Spirulina on blood and kidney in mice.Methods: Twenty Swiss Albino mice (Mus musculus) were randomly divided into 4 equal groups’ viz., A, B, C, and D. Group A was kept as control and fed only normal diet. Group B was supplemented with acetaminophen where as group C was supplemented with acetaminophen and Spirulina, and group D was treated with Spirulina.Results: The application of acetaminophen did not have significant effect on hemoglobin and uric acid content. But the addition of Spirulina to the diet increased significantly (P<0.05) hemoglobin and uric acid level. Histopathological examination revealed that no significant changes were found in the kidney of all of treated groups in comparison with the mice of control group.Conclusions: The research work suggests that long-term ingestion of acetaminophen does not exert a significant change in hemoglobin or uric acid level but spirulina supplemented diet may be associated with the rise in hemoglobin and uric acid level without affecting renal tissue texture in a significant manner.