Open AccessSTRATEGY FOR THE DIAGNOSTICS OF TOXOPLASMOSIS IN DIFFERENT POPULATION GROUPS
Author(s) -
D.B. Goncharov,
E.V. Abbazova,
V.A. Kovaleva,
B.I. Maracusha,
I.V. Titova
Publication year - 2021
Publication title -
medicinskaâ parazitologiâ i parazitarnye bolezni
Language(s) - English
Resource type - Journals
eISSN - 2713-1777
pISSN - 0025-8326
DOI - 10.33092/0025-8326mp2021.1.29-36
Subject(s) - toxoplasmosis , toxoplasma gondii , immunology , antibody , population , disease , stage (stratigraphy) , medicine , biology , pathology , environmental health , paleontology
The analysis of laboratory examination of the population with latent and chronic toxoplasmosis has a number of complexities. Therefore, the search for accurate biomarkers of toxoplasmosis to differentiate the stage of invasion development is very important. From the group of 559 persons, the infection of T. gondii was found in 27,9%. It is shown that a person is more often infected in childhood, teenage years and adolescence, which is marked by the presence of IgM antibodies and high levels of IgG antibodies. It was confirmed that IgA antibodies is an effective marker of reactivation of latent toxoplasmosis. The laboratory determination of toxoplasmosis markers showed a significant heterogeneity of the study group in terms of the level of invasion, depending on age, as well as the possibility to identify the stage and duration of the disease, including reactivation. Keyword: toxoplasmosis, antibody detection, latent invasion, reactivation, immunological diagnostics