Open AccessNEUROPROTECTIVE ACTIVITY OF EXTRACT OF CELERY (APIUM GRAVEOLENS) IN INSILICO STUDY
Author(s) -
Reza Mahendra,
Ainul Rofik,
Hotimah Masdan Salim,
Maria Ulfa,
Evy Silvia Awwaliyah
Publication year - 2021
Publication title -
medical and health science journal
Language(s) - English
Resource type - Journals
eISSN - 2549-7596
pISSN - 2549-7588
DOI - 10.33086/mhsj.v5i2.2362
Subject(s) - apium graveolens , neuroprotection , neurotransmitter , apiaceae , metabolite , pharmacology , medicine , biochemistry , chemistry , biology , botany , receptor
Backround: Celery (Apium graveolens L., Apiaceae) is one of the medicinal plants with secondary metabolite components that have pharmacological effects such as vitamin (choline) content. This study aims to evaluate the mechanism and interaction of choline contained in celery on its effectiveness as a neuroprotective.Methods: This research is an experimental research using the in silico study.Results: The insilico search found that the choline content in celery binds to Slc5a7, Chat and Ache. Which has a function in the process of neurotransmitter biosynthesis, neurotransmitter metabolic processes and neurotransmitter secretion processesConclusion: The celery (Apium graveolens L., Apiaceae) have pharmacological activity as neuroprotective through the interaction of Slc5a7, Chat and Ache