Open AccessAssessment of Platelet Indices Profile of Pregnant Women Attending University of Abuja Teaching Hospital, Nigeria
Author(s) -
Amos Dangana,
Anthony Uchenna Emeribe,
Hezekiah Alkali Isah,
Shuaibu Saidu Musa,
J. M. Abu,
Solomon Oloche Onoja,
Nkechi Blessing Onukegbe,
Idris Nasir Abdullahi
Publication year - 2021
Publication title -
indonesian journal of medical laboratory science and technology (online)/indonesian journal of medical laboratory science and technology
Language(s) - English
Resource type - Journals
eISSN - 2656-9825
pISSN - 2684-6748
DOI - 10.33086/ijmlst.v3i2.2110
Subject(s) - platelet , mean platelet volume , medicine , hematology analyzer , hemostasis , gestation , obstetrics , case control study , post hoc analysis , significant difference , complete blood count , hematology , pregnancy , biology , genetics
Platelets initiate hemostasis by aggregating at the site of injury and participate in ensuring endothelial integrity. A defect in this process could lead to intravascular blood loss. This case-control study sought to determine the platelet counts and indices among pregnant women in the University of Abuja Teaching Hospital Gwagwalada, Abuja, Nigeria. A total of 120 pregnant women as case and 60 non-pregnant women as control were enrolled for this study. Blood samples were collected in EDTA tubes, and complete platelet count and indices were carried out using an automated five-part haematology analyzer. The mean ± standard deviation of the platelets count among the pregnant women, 226.54 ± 69.76 109 cells/L was not significantly different from that of the non-pregnant women, 214.95 ± 52.22x 109 cells/L (p=0.295). There was a significant differences in mean platelets volume (MPV) of the case and control groups (p=0.036). After post-hoc test, the significant difference was between the pregnant women in 3rd trimester and the control group (p=0.014). However, there was no diffences in the mena platelets larger cell ratio and platelet distribution width in the case and control groups. Fifteen (11.0%) and 7 (12.1%) of the case and control control groups, respectively had mild thrombocytopenia. However, there was no significant association between pregnant status and thrombocytopenia (p=0.836). Based on these findngs, it can be infered that platelet count and MPV decreases while PDW increase with the progression of gestation age compared to the non-pregnant women.