Biological Evaluation of Quaternary bis Ammonium Salt and Cetylpyridinum Bromide Against S. epidermidis biofilm | Zendy

Justyna Stefańska | Zendy; Anna Pietruczuk-Padzik | Zendy; Marta Struga | Zendy; Maciej Borkowski | Zendy; Stefan Tyski | Zendy

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Biological Evaluation of Quaternary bis Ammonium Salt and Cetylpyridinum Bromide Against S. epidermidis biofilm

Author(s) -

Justyna Stefańska,

Anna Pietruczuk-Padzik,

Marta Struga,

Maciej Borkowski,

Stefan Tyski

Publication year - 2013

Publication title -

polish journal of microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.312

H-Index - 34

eISSN - 2544-4646

pISSN - 1733-1331

DOI - 10.33073/pjm-2013-049

Subject(s) - ammonium , salt (chemistry) , biofilm , bromide , chemistry , staphylococcus epidermidis , quaternary , microbiology and biotechnology , nuclear chemistry , bacteria , inorganic chemistry , biology , organic chemistry , staphylococcus aureus , genetics , paleontology

Quaternary ammonium compounds are broad-spectrum bacteriocides widely used as antiseptics, disinfection and preservation agents. The aim of this study was to examine the activity of two quaternary ammonium salts, cetylpyridinum bromide and a newly synthesized quaternary bis ammonium salt, against S. epidermidis biofilm. The average values of killing efficiency for cetylpyridinum bromide ranged from 26.6% to 64.1% for all tested concentrations (0.125 to 8.0 microg x mL(-1)) and for quaternary bis ammonium salt the percentage of killing efficiency ranged from 59.7% to 88.4% for tested concentrations (from 2.0 to 128.0 microg x mL(-1)). Both tested compounds significantly affect staphylococcal biofilms, but any of used concentrations caused a total eradication of bacterial biofilm.

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