Open AccessSub-chronic exposure to Leachate from Ojota, Lagos is associated with Liver and kidney toxicity in Rats
Author(s) -
Abiola Muhammad Adeosun
Publication year - 2022
Publication title -
fudma journal of sciences
Language(s) - English
Resource type - Journals
ISSN - 2616-1370
DOI - 10.33003/fjs-2022-0601-829
Subject(s) - leachate , distilled water , toxicity , alkaline phosphatase , bilirubin , creatinine , liver function , chemistry , medicine , kidney , urea , renal function , zoology , endocrinology , toxicology , biology , biochemistry , environmental chemistry , enzyme , chromatography
This study evaluated the toxicity of Leachate from Ojota, Lagos dumpsite on the kidney and liver of male Wistar rats. Forty-five male albino rats weighing 180 ±5.5 grams were randomly divided into five groups (n=9). Group A rats drank distilled water throughout the experimental period while rats in group B, C, D and E were exposed to 25%, 50%, 75% and 100% leachate via drinking water for 45 days respectively. Daily intake of leachate was measured for each group. On the last day, the animals were fasted 8 hours overnight and blood samples were collected for liver and kidney function tests. Our finding revealed that rats exposed to 25%, 50% and 75% drank more of the leachate. There were marked increase (P<0.05) in the activities of aspartate aminotransferase (AST) and alkaline phosphatase (ALP) in rats exposed to different concentrations of the leachate. Rats exposed to 75% and 100% leachate showed significant increase (P<0.05) in serum Alanine aminotransferase (ALT) activity, γ-glutamyltransferase (GGT) activity was higher in other groups compared to control, while rats exposed to 25% and 50% leachate had increase in the serum direct bilirubin concentration (P<0.05). Creatinine level was markedly high in rats exposed to 100% leachate while the rats that were exposed to 50% and 100% leachate had elevated urea level. Conclusively, leakage of leachate into water bodies especially ground water and its exposure through drinking may pose a high risk on liver and kidney function.