Open AccessCross-linking of DNA Segments by Histone H1 Explains H1 Associated Phenomena of Chromatin Folding
Author(s) -
Q. Anwar Hamid,
Ojaswee Dahal,
Osama Dasti,
Ziledar Ali
Publication year - 2019
Publication title -
science documents
Language(s) - English
Resource type - Journals
eISSN - 2574-1721
pISSN - 2573-1882
DOI - 10.32954/synsdocs.2019.001.03
Subject(s) - chromatin , histone , histone h1 , dna , biophysics , chemistry , folding (dsp implementation) , linker dna , histone code , microbiology and biotechnology , biochemistry , nucleosome , biology , electrical engineering , engineering
Molecular mechanism for the cooperative and non-cooperative binding of histone H1 to DNA, its rearrangement and exchangebetween chromatin fibers and its role in the folding of interphase chromatin are proposed in this communication. The mechanism ofH1 binding to DNA described here is simple and is based on two established facts; (i) histone H1 can crosslink two DNA segmentsthrough salt bridge formation between its positively charged lysine and arginine residues and the negatively charged phosphodiesterbonds of the DNA segments, (ii) cations reduce the negative charges on DNA segments and thus decrease the force of repulsionbetween them.