Open AccessAssociation of Breast Cancer and In situ expression of Interleukin-4 (IL-4) and IL-10.
Author(s) -
Salman H. Amal
Publication year - 2010
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v8i2.330
Subject(s) - in situ hybridization , breast cancer , in situ , pathogenesis , medicine , pathology , cancer , oncology , messenger rna , biology , chemistry , gene , biochemistry , organic chemistry
Estimation of the in situ hybridization expression of IL-4and IL-10 in patients with malignant breast cancer.A technique utilizing in situ hybridization (ISH) was performed to detect and determine the in situ expression of IL-4 and IL-10 mRNA using paraffin embedded sections .Samples obtained from archive of department of pathology of two hospitals in Baghdad for 60 patients, who were divided into two groups:30 with malignant breast cancer (group-1) and 30 woman with nonmalignant as a control group (group-2).The levels of the in situ expression of both IL-4 and IL-10 mRNA were found to be a highly significant increased in group 1 as compared with group 2 (p 0.05) in all studied group.The increasing expression of IL-4 and IL-10 in malignant breast cancer tissue might be influence in the pathogenesis of malignant breast cancer.