Open AccessOxidative Stress and Antioxidant Status in Human InfectedWith Kala-azar
Author(s) -
Basma T. Jasim,
Ahmed A. M. Al-Azzauy
Publication year - 2009
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v6i1.365
Subject(s) - malondialdehyde , oxidative stress , glutathione , antioxidant , reactive oxygen species , medicine , pharmacology , immunology , biology , biochemistry , enzyme
Malondialdehyde (MDA) is the most commonly marker that is used to investigate the presence of oxidative stress in biological system, and glutathioneredox cycle is a major antioxidant defense system for the detoxification of reactive oxygen species (ROS) within erythrocyte.In the present study, we aimed to evaluate erythrocyte malondialdehyde (MDA) as an indicator for the oxidative status and erythrocyte reduced glutathione (GSH) level as indicators for the antioxidative status in Kala-azar patients.The study included sixty patient with Kala-azar and they were followedup after their complete chemotherapy with antileishmanial drug (sodium stibogluconate) for (4) weeks. Seventy normal healthy individuals of age and sex match who served as control. After data analysis the following observationswere obtained, erythrocyte (MDA) and (GSH) level were significantly increased in Kala-azar patients as compared with normal healthy controls. After treatment, erythrocyte (MDA) and (GSH) level had decreased significantly as compared to patients before treatment groups. The results suggest that Kala-azar patients are in oxidative stress which most likely induces the endogenous antioxidant such as (GSH).