Open AccessTrophoblast-Expression of Interleukin-6 (IL-6) and Human Chorionic Gonadotropin (hCG) inWomen with Recurrent Abortion ComparedWith Normal Pregnancy
Author(s) -
Salman H. Amal,
Al-Zubaidy A. Ghaith,
Hussain A. Suraf
Publication year - 2008
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v5i1.398
Subject(s) - immunohistochemistry , human chorionic gonadotropin , trophoblast , pregnancy , abortion , gonadotropin , chorionic villi , medicine , andrology , curettage , gynecology , biology , fetus , placenta , hormone , pathology , genetics
Objective:We studied the estimation of IL-6 and hCG expression in immunohistochemistry in women with unexplained Recurrent Spontaneous Abortion (RSA) and find out whether or not IL-6 regulates human Chorionic Gonadotropin release (hCG).An immunohistochemistry technique was performed to detect and determine the immunohistochemistry expression of IL-6 and hCG proteins using paraffin embedded sections of curettage samples obtained from 50 women, who were divided into three groups: 25 women with RSA, 15 women with abortionfor the first time, and 10 women with induced abortion.The levels of the immunohistochemistry expression of both IL-6 and hCG were found to be highly significant increased in group 3 as compared with group 1 and group 2 (P<0.001), with a significant positive correlation between these two parameters (P<0.05) in three groups.
The trophoblasts expression of IL-6 might play a role in stimulation of the expression of hCG during pregnancy.