Open AccessAssay of Metronidazole from Different Manufacturing Sources in Iraqi Markets
Author(s) -
N. Al-Sabea
Publication year - 2008
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v5i1.373
Subject(s) - metronidazole , dosage form , high performance liquid chromatography , chromatography , calibration curve , mathematics , chemistry , antibiotics , detection limit , biochemistry
Metronidazole is an antibacterial agent that is effective in treatment of anaerobic infection. It can be assayed using HPLC to estimate the weight of theactive constituent of the drug in the specific dosage form.
In this work we used the HPLC techniques to estimate the exact amount of Metronidazole in samples, which are Metronidazole tablet 200 mg from differentpharmaceutical companies in Iraq pharmaceutical market to evaluate the content of drug in dosage form in these samples.The experimental work includes making calibration curve using standard solutions of different concentrations of the external standard metronidazole USP2002. Different readings of the area under the peak were obtained following the straight line equation.The result show that all of five samples are within maximum percentage of the differences allowed (95-105%) according to the B.P 2003.