Open AccessNEW DRUG DELIVERY SYSTEM OF DICLOFENAC SODIUM FOR ITS APPLICATION IN THERAPEUTIC EMBOLIZATION STRATEGY.
Author(s) -
Nidhal Khazaal Marie
Publication year - 2007
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v4i1.384
Subject(s) - diclofenac sodium , microsphere , drug delivery , plga , drug , chemistry , biomedical engineering , diclofenac , dissolution , materials science , chromatography , pharmacology , chemical engineering , nanotechnology , medicine , organic chemistry , nanoparticle , biochemistry , engineering
The perfectly spherical microspheres of the ion- exchange resins diethylaminoethyl – trisacryl (DEAE) had been successfully used for achieving mechanical occlusion of vascular lumen. In this study; diclofenac sodium is reversibly adsorbed onto DEAE microspheres (28.3 g drug / 100 g of microspheres). The dissolution profile showed rapid release of the drug from the loaded microspheres, and since this may lead to dramatic decrease in the drug before the microspheres. reaches the targeted site, therefore, microencapsulation of the drug loaded DEAE microspheres is carried out for the first time in this study using PLGA as a coating polymer and applying two different methods of microencapsulation. The results showed that increasing the amount of PLGA lead tomore retardation in the release of the drug through affecting core : coat ratio and the mechanism of drug release. It is also found that applying emulsification / solvent evaporation method with 60% w/w PLGA gave regular retarded release microcapsules with better sphericity, which may be easily injected by a catheter at the required site and offers a new drug delivery system and new application for diclofenac sodium in the promising strategy of using embolization particles with anti – inflammatory activity.