Open AccessEffect of metformin and antioxidant agents on oxidative stress status and follicular maturation in women with polycystic ovary syndrome
Author(s) -
Sulaiman R. Waleed,
Al-Omari R. Wafa,
Taher A. Mohammed
Publication year - 2006
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v3i1.406
Subject(s) - metformin , polycystic ovary , malondialdehyde , oxidative stress , medicine , follicular phase , endocrinology , vitamin e , antioxidant , metabolite , vitamin c , insulin resistance , chemistry , obesity , insulin , biochemistry
In this study, forty-two Iraqi Arab Women with PCOS were involved and they were classified into three groups according to type of treatment:1) Group І: fourteen patients who administered metformin (500mg t.i.d).2) Group П: fourteen patients who administered combination of metformin (500mg t.i.d) with vitamin C (250mg t.i.d)3) Group PI: fourteen patients who administered combination of metformin (500mg t.i.d) with vitamin E (200mg t.i.d).All groups were treated for three months .The present study includes the measurement of serum malondialdehyde, Vitamin E and its metabolite (tocopheronic acid) play an important role in alleviation of oxidative stress(MDA) and may potentiate the metformin activity in maturation of follicles