Effect of metformin and antioxidant agents on oxidative stress status and follicular maturation in women with polycystic ovary syndrome | Zendy

Sulaiman R. Waleed | Zendy; Al-Omari R. Wafa | Zendy; Taher A. Mohammed | Zendy

Open Access

Effect of metformin and antioxidant agents on oxidative stress status and follicular maturation in women with polycystic ovary syndrome

Author(s) -

Sulaiman R. Waleed,

Al-Omari R. Wafa,

Taher A. Mohammed

Publication year - 2006

Publication title -

al mustansiriyah journal of pharmaceutical sciences

Language(s) - English

Resource type - Journals

eISSN - 2959-183X

pISSN - 1815-0993

DOI - 10.32947/ajps.v3i1.406

Subject(s) - metformin , polycystic ovary , malondialdehyde , oxidative stress , medicine , follicular phase , endocrinology , vitamin e , antioxidant , metabolite , vitamin c , insulin resistance , chemistry , obesity , insulin , biochemistry

In this study, forty-two Iraqi Arab Women with PCOS were involved and they were classified into three groups according to type of treatment:1) Group І: fourteen patients who administered metformin (500mg t.i.d).2) Group П: fourteen patients who administered combination of metformin (500mg t.i.d) with vitamin C (250mg t.i.d)3) Group PI: fourteen patients who administered combination of metformin (500mg t.i.d) with vitamin E (200mg t.i.d).All groups were treated for three months .The present study includes the measurement of serum malondialdehyde, Vitamin E and its metabolite (tocopheronic acid) play an important role in alleviation of oxidative stress(MDA) and may potentiate the metformin activity in maturation of follicles

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