Open AccessSynthesis and characterization of benzylidene- [1,3,4]thaidiazol -2-yl-amine
Author(s) -
Al-Kaddimy H. A. Ahmed
Publication year - 2006
Publication title -
al mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v3i1.405
Subject(s) - potassium hydroxide , chemistry , yield (engineering) , anhydrous , schiff base , carbon disulfide , aldehyde , ethanol , amine gas treating , organic chemistry , potassium carbonate , base (topology) , amino acid , medicinal chemistry , nuclear chemistry , polymer chemistry , catalysis , materials science , mathematical analysis , mathematics , metallurgy , biochemistry
This study was designed to synthesize chemically 2-aminothiadiazole derivatives and conversion to Schiff’s base. The principle synthesis of these compounds was to involve three steps:First : by thermal cyclization of thiosemicarbazied with carbon disulfide in the presence of potassium hydroxide dissolved in anhydrous ethanol to yield 2-amino-5- mercapto-1,3,4-thiadiazole.Second : by thermal cyclization of thiosemicarbazied with substituted carboxylic acid and sulphuric acid, to yield 2-amino-5-R-1,3,4-thiadiazole.Third : Schiff’s base formation by reflux of aromatic aldehyde with 2-amino-5-R-1,3,4-thiadiazole in the presence of ethanol.The chemical structures of all prepared compounds were confirmed by spectral data (UV-visible and IR spectroscopy) tables (1, 2, and 3).
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