Open AccessSome Variables Affecting Microencapsulation of d–alpha Tocopherol Succinate
Author(s) -
Khalil I. Yehia
Publication year - 2006
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v3i1.401
Subject(s) - dissolution , chemistry , tocopherol , vitamin e , alpha tocopherol , ethyl cellulose , cellulose , core (optical fiber) , polymer , chromatography , nuclear chemistry , chemical engineering , materials science , organic chemistry , composite material , antioxidant , engineering
d-alpha tocopherol succinate, (Vit.E) is one of the most important vitamin, that is incorporated in food and nourishment due to its high biological activity against free radical formation inside cells.This study was illustrated in the followings:- Microcapsules of d - alpha tocopherol were prepared from different core:wall ratios 1:1 , 1:2 and 1:3 by solid dispersion method using ethyl cellulose (Ethoel ®) polymer .- The powdered microcapsules with 1:1 core:wall ratio is formulated as tablets with good appearance and hardness.- The drug release was found to be increased as a function of increasing, core:wall ratio, stirring speed and pH – medium.- The profile of cumulative different pH – medium release of the drug gives rise an indication of prolonged release dosage form. “ during 6hrs. of dissolution”