Open AccessDermatophytoses and the High Level of CR3 (CD11b/CD18)
Author(s) -
Hafidh R. Rand,
Abdul Muhaimen Nidhal,
Dabbagh Rasool
Publication year - 2005
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v2i2.429
Subject(s) - integrin alpha m , downregulation and upregulation , microbiology and biotechnology , immunology , receptor , antigen , cd18 , medicine , fungus , biology , chemistry , immune system , biochemistry , botany , gene
In patients infected with dermatophytoses there is a continuous fungal antigen shedding into the circulation, especially during chronic infection, including the cell wall component beta-glucan as one of the fungal antigen. CR3 (CD11b/CD18) serves as a leukocyte receptor for particulate and soluble betaglucan.The keratinocyte induction by the fungus; to produce certain cytokines and their role in the upregulation of CD11b expression. All can explain our results with the high level of CD11b expression in dermatophytic patients in comparison to controls group, and in chronically infected patients more than in acutely infected patients.