Open AccessEffect of new synthesized piperazine derivative [1] containing 1, 2, 4 –triazole ring on the growth of some pathogenic microorganisms
Author(s) -
Al-SamaraieW. Khulood,
Al-Rahbi S. Omar,
Al-Nasiri A. Nazar
Publication year - 2005
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v2i1.416
Subject(s) - piperazine , trichophyton rubrum , antimicrobial , staphylococcus aureus , escherichia coli , chemistry , antibacterial activity , minimum inhibitory concentration , trichophyton , 1,2,4 triazole , pathogenic bacteria , acetic acid , dermatophyte , microbiology and biotechnology , nuclear chemistry , bacteria , organic chemistry , biology , biochemistry , antifungal , genetics , gene
This work describes the antimicrobial activity of newly synthesized 4-methyl (3-mercapto -4- phenyl -4H- 1,2,4-Triazole –5-yl) methyl piperazine. [1]. The newly synthesized piperazine derivative was obtained from basic cyclization of the intermediate product obtained from the reaction between acetic hydrizide –4-methyl piperazine and phenylisothiosyanate(1) .[1] The in vitro tests showed antimicrobial activity against two pathogenic bacteria viz; Staphylococcus aureus (gram positive) and Escherichia coli (gram negative), in addition to the dermatophyte pathogenic fungi Trichophyton rubrum. The screening antibacterial results illustrated below indicate that concentration [50mg/ml] showed the highest inhibitory effect against Escherichia coli, while the same concentration has a moderate activity againstStaphylococcus aureus.While the highest inhibitory effect against Trichophyton rubrum was achieved using the concentration [25 mg/ml].