Open AccessSynthesis, Antibacterial study and ADME Evaluation of Novel Isonicotinoyl Hydrazide Derivative Containing 1,3,4-Oxadiazole Moiety
Author(s) -
Mazen Mohammed Jwaid,
Karima Fadhil Ali,
Mayada Hadi Abd_alwahab
Publication year - 2022
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v20i4.781
Subject(s) - adme , pharmacophore , chemistry , hydrazide , moiety , lipinski's rule of five , antibacterial activity , combinatorial chemistry , agar diffusion test , stereochemistry , bioavailability , derivative (finance) , bacteria , organic chemistry , escherichia coli , biochemistry , in silico , pharmacology , biology , economics , financial economics , in vitro , gene , genetics
Novel derivative of isoniazid containing 1,3,4-oxadiazole pharmacophore has been synthesized. The chemical structure of the compound was characterized and confirmed by using FT-IR and 1H-NMR spectroscopy.
The desired compound was tested against gram-positive and gram-negative bacteria using agar well-diffusion technique for their ability as antibacterial agent and showed good antibacterial activity against gram-negative bacteria and gram-positive bacteria. In addition, ADME evaluations were performed using Swiss ADME to predict if the synthesized compound can be given orally, the bioavailability, topological polar surface area, and drug-likeness. The result showed that all tested compounds absorbed orally and fulfilled the Lipinski rule.