Open AccessPreparation And Characterization Of Nimesulide Nanoparticles For Dissolution Improvement
Author(s) -
Inas F. Abd-AlRazaq,
Firas Aziz Rahi,
Mohammed S. Al-lami
Publication year - 2018
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v18i1.458
Subject(s) - nimesulide , dissolution , solubility , particle size , nanoparticle , differential scanning calorimetry , antipyretic , materials science , precipitation , chemistry , chemical engineering , chromatography , nuclear chemistry , organic chemistry , nanotechnology , analgesic , pharmacology , medicine , biochemistry , physics , meteorology , engineering , thermodynamics
Nimesulide is one of the types of non-steroidal anti-inflammatory drugs, widely used as analgesic and antipyretic. It is classified as class II drugs according to BCS guidance because of low solubility in water that leads to decrease in dissolution rate. So the objective of this study was to decrease particle size, increase solubility and dissolution rate of nimesulide by preparation of nimesulide nanoparticles using solvent/antisolvent precipitation method by addition of organic solution of drug onto the solution of stabilizer. The size of nimesulide nanoparticles were studied and considered by particle size analyzer, drug content and loading efficiency. The freeze dried nanoparticles were characterized by field emission electron microscope, X-Ray powder diffraction, differential scanning calorimetry and saturated solubility measurement. Tablet was manufactured by direct compression. The tablets were evaluated for drug release to measure the effect of nanoparticles on the dissolution improvement of drug.