Open AccessEffects 0f Aliskiren on the Absorption of Monosaccharides in Animal Model of Fructose-induced Metabolic Syndrome
Author(s) -
Saad Abdulrahman Hussain,
Rbab Mohammed Utba,
Zheen Orahman Ahmed,
Tavga Ahmed Aziz
Publication year - 2018
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v17i2.45
Subject(s) - aliskiren , medicine , endocrinology , fructose , triglyceride , chemistry , monosaccharide , insulin , metabolic syndrome , adipose tissue , absorption (acoustics) , carbohydrate metabolism , cholesterol , renin–angiotensin system , diabetes mellitus , biochemistry , blood pressure , physics , acoustics
The renin angiotensin system (RAS) was involved in various metabolic processes including insulin secretion, carbohydrate absorption and proliferation of adipose tissue. This study aims to evaluate the effects of aliskiren on the absorption of glucose in rats with fructose-induced metabolic syndrome. The results showed that treatment with aliskiren attenuates the increase in body weight and improves fasting serum glucose, insulin, triglycerides and cholesterol levels. Moreover, absorption of glucose was significantly decreased after oral glucose load in high-fructose diet fed rats. In conclusion, aliskiren significantly reduces body weight, fasting serum glucose, insulin, triglyceride and total cholesterol levels, and the rate of glucose absorption after oral glucose load in high fructose-fed rats.