Open AccessEvaluationoof0theoRole0ofoGabapentin0and/oroOmega-30in0Uremic Pruritusofor0PatientsoUndergoing0Hemodialysis0
Author(s) -
Sinan Forat Hussein,
Kadhim Ali Kadhim,
Ali Jassim Al_Sultani,
Saad Abdulrahman Hussain
Publication year - 2017
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v17i2.157
Subject(s) - medicine , gabapentin , stage (stratigraphy) , parathyroid hormone , gastroenterology , drug , pharmacology , biology , pathology , alternative medicine , calcium , paleontology
Uremicopruritus,0isochronic0itchingothat0occursoin0patientsowith0advancedoor0 end-stage renal0disease.oIt0isoone0ofocommon0symptomsoinopatients00with00end-stage renal0 diseaseowith0approximatelyo60–90%0ofopatients0on0hemodialysis(HD) suffering0fromothis0problem. This study wasodesigned0to evaluate theoefficacy0and safety of prescribing Gabapentinoand0Omega-3 in combination or aloneofor0relieving uremicopruritus0in Iraqi patients undergoing0hemodialysis. The resultsoshowed0that all the threeoinvolved0regimens0(gabapentin, omega-3,0and the combinationoof0both drugs) had0significantly reduced the pruritus score. Furthermore,0theocombination0was significantlyosuperior0tooother0regimens in reducingopruritus 0score, owhile0no0significant effect0wasoobserved0by oallothe regimensoon0interleukin-6oor0on parathyroid hormone serum0levels.In Conclusion Gabapentin0100mgoplus01000mg0omega-30based fishooil capsules containing 120mg0DHA and0180mg0EPA isosuperior0to each drug alone0in reducing pruritus scoreoin0a0sample0of Iraqi0patients.