Open AccessDesign and Synthesis of new Naproxen Analogues as Potential Anti-inflammatory Agents
Author(s) -
Noor H. Nasser,
Nethal H. Hammud,
Samer A. Hasan,
Abbas Hamid Abdalsadh,
Ahmed kareem Hussein
Publication year - 2018
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v17i1.61
Subject(s) - naproxen , anti inflammatory , chemistry , selectivity , drug , enzyme , fourier transform infrared spectroscopy , microanalysis , organic chemistry , combinatorial chemistry , stereochemistry , nuclear chemistry , pharmacology , catalysis , chemical engineering , medicine , alternative medicine , pathology , engineering
4-aminobenzenesulfonamide derivatives were linked to α-carbon of naproxen a non-selective non-steroidal anti-inflammatory drug (NSAID) to increase its size, so; increase its selectivity toward COX-2 enzyme, rather than COX-1 enzyme, that lead to reduce gastrointestinal side effects of this drug.The chemical structures of the synthesized compounds and their intermediates were confirmed and characterized using elemental microanalysis (CHN), FTIR, and other physicochemical properties like melting points, Rf values.