Open AccessSynthesis, Characterization and Antibacterial Studies of 2-azetidinones Compounds Derived from Amoxicillin
Author(s) -
Entesar O. Al-Tamimi,
Raad M. Muslih,
Khalida A. Thejeel
Publication year - 2015
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v15i1.160
Subject(s) - amoxicillin , triethylamine , antibacterial activity , chloroacetyl chloride , chemistry , antibacterial agent , chloride , organic chemistry , bacteria , antibiotics , biology , biochemistry , genetics
In this study, the new azetidinones were synthesized from Schiff bases 2(a-j) that derived from amoxicillin (1) on treatment with chloroacetyl chloride in presence of triethylamine gave azetidinone 3(a-j). The structure of these compounds have been elucidated on the basis of their physical and spectral. Azetidinone compounds were also screened for their antibacterial activity against some bacterial species using amoxicillin as standard.