Open AccessModification of Polyvinyl Pyrrolidinone, Chitosan with Paracetamol As a Drug Carrier Polymer
Author(s) -
Firyal M. Ali,
Luma Amer Musa,
Amany Sabri Younis
Publication year - 2014
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v14i1.133
Subject(s) - chitosan , polymer , polymer chemistry , materials science , drug , chemical engineering , chemistry , nuclear chemistry , organic chemistry , pharmacology , medicine , engineering
The drug polymer was prepared by modification of polyvinylpyrrolidinone (PVP) withparacetamol through ester group formation, and partially ring opening of PVP withparacetomol, could let the chitosan to graft on other rings of PVP.Also the NH2 group of chitosan was reacted with PVP produced a new copolymerbiopolymer; the prepared polymers were characterized by UV, FT-IR,1H-NMRSpectroscopies, DSC thermal analysis was carried out.Controlled drug release was studied in different PH values. The physical propertiesand intrinsic viscosity were measured. The work aimed to prolong the sustainable drugdelivery system.