Open AccessPreparation of Polyvinylpyrrolidinone With Paracetamol as Drug Polymer
Author(s) -
Firyal M.A.AL-Salami,
Abbas N.M.AL-Sharify,
J K Khudheyer
Publication year - 2012
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v11i1.251
Subject(s) - prodrug , hydrolysis , polymer , chemistry , drug , viscosity , base (topology) , organic chemistry , nuclear chemistry , polymer chemistry , chromatography , materials science , biochemistry , pharmacology , medicine , mathematical analysis , mathematics , composite material
The prodrug polymer was prepared according to ring opening of polyvinyl pyrrollidinone with nuecleophilic attack of hydroxyl group of paracetamol.The new colorless drug polymer was formed with 92% conversion percentage with intrinsic viscosity was equal to (0.61dl/g). The drug polymer wascharacterized and identified by1H-NMR, IR and UV. Spectroscopy. Controlled released rates were studied in acidic and basic medium at 30 0C and 40 0C.Rate of hydrolysis of paracetamolate ester acts as base > acid, and the rate of release, depends on temperature and pH values. The results show higher hydrolysis at higher temperature as well as higher pH value.