Open AccessStudy on Dissolution test and the correlation factors that lead to different Bioavailability of Drugs
Author(s) -
Rinata Abed Al star-Abed AL-Hussein,
Kassim Mahdi Wadi,
Abdulkhaliq A. Al-Naqeeb
Publication year - 2011
Publication title -
almustansiriya journal of pharmaceutical sciences/al-mustansiriyah journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2959-183X
pISSN - 1815-0993
DOI - 10.32947/ajps.v10i2.292
Subject(s) - solubility , bioavailability , significant difference , chemistry , dissolution , mathematics , medicine , pharmacology , statistics , organic chemistry
The aim of this work is to study the physical and chemical characteristics solubility testing by using three types of drugs which are: (Clopidegrol tablet, Simvastatin tablet, Chlorpromazine tablet).
From different sources (France, Jordan, India, Germany, Creek, Syria and Lebanon) according to American standard (U.S.P30) to obtain the results to the primary solubility testing data the result of the significant level comparison to analysis the variation for the test of equal means of the data of solubility as following:1 - The solubility of the French drug is the heights with significant level differences at:A - With a highly significant level (P 0.05) Compared with Jordan product.C - A highly significant level at (P 0.05) compared with Indian product .4 - Show that their exist a significant difference (P < 0.05) with the highly solubility for the Lebanon product compared with Syrian product by also using chlorpromazine in similarly test for average reading of solubility by using t-test.