Open AccessNew Nanosized Systems with Antitumor Activity Based on the Pt(IV) Complexes with Nicotinamide Ligands and Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylate
Author(s) -
S. V. Kurmaz,
AUTHOR_ID,
Д. В. Конев,
V. A. Kurmaz,
Г. И. Козуб,
V. M. Ignat’ev,
N. S. Emel’yanova,
А. А. Балакина,
A. A. Terentyev,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID,
AUTHOR_ID
Publication year - 2022
Publication title -
inèos open
Language(s) - English
Resource type - Journals
ISSN - 2658-5618
DOI - 10.32931/io2123a
Subject(s) - copolymer , amphiphile , methacrylate , polymer chemistry , chemistry , polymer , combinatorial chemistry , materials science , organic chemistry
The nanosized systems involving Pt(IV) complexes with antitumor activity are obtained by their solubilization via amphiphilic copolymers of N-vinylpyrrolidone and (di)methacrylates synthesized by the radical copolymerization in toluene without any polymer chain growth terminating agents. The resulting systems are investigated by a complex of physico-chemical methods (IR spectroscopy, DLS, TEM, cyclic and square-wave voltammetry) and quantum chemical simulation. The Pt(IV) complexes are shown to have cytotoxic effects on A-172 tumor cells and the corresponding cytotoxicity indices (IC50) are determined. The amphiphilic copolymers under consideration are promising modern platforms and delivery vehicles for biologically active compounds.