C-Oxyalkylation of Arylamines, Enamines, and Nitrogen-Containing Heterocycles with Polyfluorinated Carbonyl Compounds as a Synthetic Route to Biologically Active Compounds

Using hexafluoroacetone and trifluoropyruvic acid esters as representative examples, the results of investigations on the reactions of polyfluorinated carbonyl compounds with arylamines, cyclic azomethine–enamines, and nitrogen-containing heterocycles are reviewed. For the first time, the peculiarities of the C-oxyalkylation of nitrogen-containing π-systems with polyfluorinated carbonyl compounds are considered systematically. The results on biological assays of the resulting fluorine-containing products of the C-oxyalkylation are presented. The promising routes for further development of this field from the viewpoint of the creation of new biologically active compounds are outlined.