Open AccessTo Evaluate Anti-HLA Antibodies Sensitization in Pre- and Post-renal Transplant Patient’s Serum: A Retrospective Case Series
Author(s) -
Nishtha Agarwal,
Sanjeev Goswami
Publication year - 2019
Publication title -
journal of medical research and innovation
Language(s) - English
Resource type - Journals
ISSN - 2456-8139
DOI - 10.32892/jmri.187
Subject(s) - medicine , renal transplant , human leukocyte antigen , antibody , titer , graft rejection , complication , immunology , donor specific antibodies , gastroenterology , transplantation , surgery , antigen
In India, patients of renal failure are dependent on live related or unrelated donor. Because of poor financial condition patients do not go for DSA (Donor Specific Antibody) detection using Luminex. In absence of screening of de-novo production of DSA and don’t get proper management. As a result of which patient undergo acute rejection.
Case Series: Here we are presenting 5 acute rejection cases comparing there DSA in pre-transplant and post-transplant sera using solid-phase assays.5 renal transplanted patients undergone acute and hyperacute rejection (Banff's classification) were considered for presented case series. Collected serum (pre and post-transplant on day of rejection) from each patient was subjected to detection of anti-HLA antibody using Luminex-PRA.
Conclusion: Presence of donor-specific anti-HLA antibody with their titer was detected in pre and post-transplant serum. It is found that the strength of DSA is directly proportional to graft life.