Open AccessComparative Wound Healing Study of Ocimum tenuiflorum Leaves Extract and its Formulation on Sprague Dawley Rats
Author(s) -
Rabeta Mohd Salleh,
Rohini Jayaraman,
Nasir Yusoff
Publication year - 2021
Publication title -
asm science journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.12
H-Index - 6
eISSN - 2682-8901
pISSN - 1823-6782
DOI - 10.32802/asmscj.2021.695
Subject(s) - ocimum , wound healing , pharmacology , traditional medicine , drug , lecithin , basilicum , chemistry , medicine , chromatography , surgery
This study has been designed to compare the leaves extract of Ocimum tenuiflorum with soy lecithin and the leaves extract of Ocimum tenuiflorum only and find out its effectiveness on wound healing properties. Drug release study was also evaluated to obtain a brief idea on the release of the drug after consumption of the formulation and extract. The wound healing effectiveness study suggest that the formulated extract has better wound healing activity in comparison to extract which is more similar to the standard drug which was used as positive control. It was also found that the drug release activity of the formulation shows sustained release of the marker compound in when compared to the extract. Thus, it can be concluded that the improved wound healing activity of the formulation could be due to the sustained released of the compounds which present that act accordingly to improve the activity. Further study on its mechanism of action need to done to understand it activity better.