Open AccessComparison between Leukocyte Esterase Activity (LEA) and Histopathology Examination in Identifying Chorioamnionitis Cases
Author(s) -
Putri H Novianesari,
Nuswil Bernolian,
Maulani Henni,
Afifa Ramadanti,
Theodorus Theodorus
Publication year - 2019
Publication title -
indonesian journal of obstetrics and gynecology
Language(s) - English
Resource type - Journals
eISSN - 2338-7335
pISSN - 2338-6401
DOI - 10.32771/inajog.v7i1.823
Subject(s) - chorioamnionitis , medicine , histopathology , obstetrics , neonatal sepsis , gestational age , sepsis , pregnancy , gynecology , pathology , genetics , biology
Objective: To compare sensitivity and specificity of LEA to histopathology examination in diagnosing chorioamnionitis.
Methods: We compared diagnostic tests in dr. Mohammad Hoesin hospital, Palembang, from September 2015 to April 2016. Ninety-one pregnant women were included. LEA and histopathology examination were carried out with neonatal sepsis as main outcome. Data were analysed by SPSS version 21.0 and Med-calc statistic.
Results: Chorioamnionitis was detected in 54 (77.1%) patients with gestational period ≥37 weeks and in 16 (22.9%) patients with gestational period 0.5 was able to significantly predict chorioamnionitis with 98.6% sensitivity and 95.2% specificity, providing better accuracy in diagnosing chorioamnionitis in preterm pregnancy group.
Conclusion: LEA had a very good predictive value for chorioamnionitis with better accuracy in diagnosing chorioamnionitis in preterm pregnancy.
Keywords: Chorioamnionitis, Histopathology, Leukocyte esterase activity, Neonatal sepsis, Salafia criteria
Tujuan: Membandingkan sensitifitas dan spesifisitas diagnosis korioamnionitis antara pemeriksaan Leukocyte esterase activity (LEA) terhadap histopatologi.
Metode: Penelitian uji diagnostik dilakukan di RSUP dr. Mohammad Hoesin Palembang selama periode September 2015 – April 2016, 91 wanita hamil yang memenuhi kriteria inklusi selanjutnya dilakukan pemeriksaan LEA, Histopatologi dan luaran sepsis neonatorum. Data kemudian dianalisis dengan menggunakan software SPSS versi 21.0 dan Med-calc statistic.
Hasil: Korioamnionitis terdeteksi pada 54 (77,1%) pasien dengan usia gestasi ≥37 minggu dan 16 (22,9%) pada usia gestasi 0,5 secara signifikan mampu memprediksi kejadian korioamnionitis dengan sensitivitas 98,6%, spesifisitas 95,2% dan nilai akurasi yang lebih baik ditemukan dalam penegakan diagnosis korioamnionitis pada kelompok kehamilan preterm.
Kesimpulan: Pemeriksaan LEA memiliki kekuatan prediksi yang sangat baik terhadap kejadian korioamnionitis dengan akurasi yang lebih baik dalam mendiagnosis korioamnionitis pada kehamilan preterm.
Kata kunci: Korioamnionitis, Histopatologi, Leukocyte Esterase Activity,Sepsis Neonatorum, Kriteria Salafia