Open AccessEndothelin1 Levels in Pregnant Women with Severe Preeclampsia and Normal Pregnant Women
Author(s) -
Yosiana Wijaya,
John Wantania,
Bismarck J Laihad
Publication year - 2017
Publication title -
indonesian journal of obstetrics and gynecology
Language(s) - English
Resource type - Journals
eISSN - 2338-7335
pISSN - 2338-6401
DOI - 10.32771/inajog.v5i2.523
Subject(s) - preeclampsia , medicine , inclusion and exclusion criteria , obstetrics , pregnancy , observational study , gynecology , endothelin 1 , genetics , biology , alternative medicine , receptor , pathology
Objective: To determine the ratio of serum endothelin-1 levels between severe preeclampsia and normotensive pregnancy.
Methods: Observational analytic study using cross-sectional. Sixteen woman with normal pregnancy and sixteen others with severe preeclampsia who met the inclusion and exclusion criteria, were tested for ET-1. The serum was analyzed at Prodia Laboratory, Manado. The ET-1 level was examined using ELISA (R&D Systems, Inc., Minneapolis, MN 55413, USA). The data obtained was analyzed using SPSS software version 20.0.and discussions were held using the existing literature theory.
Results: The mean and median levels of endothelin-1 plasma in patients with severe preeclampsia is 2:46 ± 1:44 pg/ml, 1:09 ± 0:26 pg/ml, whereas in normotensive pregnancy is 1:03 ± 0:26 pg/ml,
1.95 ± 1:44 pg/ml with p < 0:05 (0000).
Conclusion: There was a significant difference between endothelin- 1 level in severe preeclampsia and normotensive pregnancies.
[Indones J Obstet Gynecol 2017; 5-2: 77-82]
Keywords: endothelin-1, normotensive, preeclampsia